While running a spy network from their elementary school, five unpopular misfits combine their enhanced abilities and use cutting-edge gadgetry to fight evil around the world.

Matilda "Wheezer" Choi, an asthmatic who uses nanobyte-enhanced inhalers and hates anything girlie, must infiltrate the cheerleading squad when former member of NERDS turned villain, Gerdie Baker, becomes a cheerleader and starts pillaging other worlds with the assistance of a device the criminal mastermind Simon helped her make.

"There's a supervillain on the loose with a deep connection to the NERDS--and she's obsessed with destroying them. Miss Information recruits her own team members and gives them supernanobytes. She calls them the Brotherhood of Unstoppable Liars, Lowlifes, and Intimidating Enemies of Society (a.k.a. the BULLIES). They have a time machine. Although Ruby "Pufferfish" Peet has terrible allergies, she's a born leader. But her abilities as a field operative...