As young boys, Edward & Alphonse Elric dabbled in alchemy to try to resurrect their dead mother. As a result, Ed lost one arm and one leg, while Al lost his entire body and had his spirit sealed into a suit of armor. Now, they are searching for the fabled Philosopher's Stone to restore what they've lost.

Ed and Alphonse try to use their newfound skills to resurrect their dead mother, but by doing so they encounter something more terrifying than death.