The Destiny continues its journey through the universe while its crew suffers from a lack of supplies and no knowledge of its final destination. Struggling to control the ship's systems, tempers and personalities of the crew clash. Facing uncharted space and enemies who would take the ship by force, the Destiny crew perseveres in the struggle to stay alive and find a way home.

Bob Lee Swagger is a master marksman who has retreated from his duty as an off-the-books hired gun for the military. He has become disillusioned with his government, but finds that the government needs Swagger to scope out the location of a rumored attempt on the life of the president. A shadowy government operative begs Swagger to use his sniper's skills to out-fox the assassin. Ultimately he is double-crosses and framed for the attempted assassination....

When a mysterious virus is brought to Earth by a returning satellite, an elite and dedicated squad of scientists assemble to search for the truth and stop the mutating killer before it ends life on Earth.

A group of soldiers, scientists, and civilians fleeing an attack find themselves stranded billions of miles from Earth on an ancient ship known as the Destiny. Locked on an unknown course, they must fight to survive and find a way home. Through the danger and adventures, some will become heroes, some will become villains, and some won't make it out at all.